New approaches to treating diverse bile duct cancers prevalent in southeast Asia

[ad_1] Credit: CC0 Public Domain An international study has effectively targeted three distinct groups in cholangiocarcinoma (CCA)—or cancer of the bile duct—with drug inhibitors. These findings, published in the journal Gut, deepen our understanding of the mechanisms that cause CCA to develop and propose new therapeutic targets for this lethal disease. This research is of…

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Research team develops new tools to improve pancreatic cancer patient care

[ad_1] Computational pathology pipeline. a,b, Images of random tumor nests selected by a pathologist in digital H&E slides (a) are sent for processing by deep-learning models to provide a mask of tumor cell nuclei (b). c, Downstream nuclear feature extraction and formation of order statistics of morphology and H&E staining features in nuclei under the…

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New approach to robotic mastectomy can preserve full breast and nipple sensation

[ad_1] Credit: Pixabay/CC0 Public Domain When I was a child, my grandma was diagnosed with breast cancer. She had a radical mastectomy at 55, which back then meant removing all her muscle, skin, and breast tissue—a disfiguring surgery that resulted in lingering pain, swelling, and complete loss of sensation in her chest. Grandma couldn’t feel…

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Study identifies new PD-1 immune checkpoint mechanism promoting Merkel cell carcinoma growth

[ad_1] Credit: Science Advances (2024). DOI: 10.1126/sciadv.adi2012 Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating various types of cancer. However, PD-1 functions can vary between different cell and cancer types, either promoting or suppressing…

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